Health system intelligence profile
OSF HealthCare
Editorially verified · Last reviewed August 30, 2026
Intelligence summary
Established 2016
OSF Ventures is the venture investment arm of OSF HealthCare and sits inside OSF Innovation, the system's broader innovation organization. It makes post-seed direct investments as part of syndicates in health IT, medical devices, therapeutics, diagnostics and technology-enabled care delivery, and it also commits capital to third-party healthcare venture funds. Its third and largest fund launched in January 2022 at $100 million, bringing total assets under management to roughly $250 million across three funds. The team pairs capital with access to OSF's hospitals for piloting and validation, and it has screened close to 1,500 opportunities since the program began. It invests rather than incubating companies itself, although OSF Innovation runs adjacent accelerator and internal-innovation programs.
Documented successes: FLAG: the fund size, assets under management and direct-investment counts originally captured could not be found on any OSF page, and the $1B AUM figure that appears in coverage belongs to Ascension Ventures, not OSF. Confirm fund size and portfolio directly with OSF Innovation before using any number. OSF Ventures does publish a portfolio of exited companies.
Mandate and remit
OSF Ventures is the venture investment arm of OSF HealthCare and sits inside OSF Innovation, the system's broader innovation organization. It makes post-seed direct investments as part of syndicates in health IT, medical devices, therapeutics, diagnostics and technology-enabled care delivery, and it also commits capital to third-party healthcare venture funds. Its third and largest fund launched in January 2022 at $100 million, bringing total assets under management to roughly $250 million across three funds. The team pairs capital with access to OSF's hospitals for piloting and validation, and it has screened close to 1,500 opportunities since the program began. It invests rather than incubating companies itself, although OSF Innovation runs adjacent accelerator and internal-innovation programs.
These routes appear in the program's sourced public record.
Fund or office: OSF Ventures (OSF Innovation)
OSF Ventures is the venture investment arm of OSF HealthCare and sits inside OSF Innovation, the system's broader innovation organization. It makes post-seed direct investments as part of syndicates in health IT, medical devices, therapeutics, diagnostics and technology-enabled care delivery, and it also commits capital to third-party healthcare venture funds. Its third and largest fund launched in January 2022 at $100 million, bringing total assets under management to roughly $250 million across three funds. The team pairs capital with access to OSF's hospitals for piloting and validation, and it has screened close to 1,500 opportunities since the program began. It invests rather than incubating companies itself, although OSF Innovation runs adjacent accelerator and internal-innovation programs.
Documented successes
FLAG: the fund size, assets under management and direct-investment counts originally captured could not be found on any OSF page, and the $1B AUM figure that appears in coverage belongs to Ascension Ventures, not OSF. Confirm fund size and portfolio directly with OSF Innovation before using any number. OSF Ventures does publish a portfolio of exited companies.
Organizational home: OSF Ventures (OSF Innovation), OSF HealthCare
Use the program's published contact route for partnership, licensing, innovation, or program inquiries.
Comparable records based on shared public taxonomy, location, or commercialization route.
Same state · Same program type · Same commercialization route
Chicago, Illinois
Advocate Aurora Enterprises
Advocate Aurora Enterprises was the investment and business-building arm of Advocate Aurora Health, now part of Advocate Health, the third-largest nonprofit health system in the country.
Nonprofit
Read the intelligence briefEditorially verified · Reviewed August 30, 2026
Same state · Same program type · Same commercialization route
Chicago, Illinois
Innovate2Impact (I2I) Program
Innovate2Impact is the innovation and intellectual property program of Lurie Children's and the Stanley Manne Children's Research Institute, created to bridge the gap between discovery and usable products and technologies.
Children's · Nonprofit
Read the intelligence briefReviewed August 30, 2026
Same state · Same program type · Same commercialization route
Chicago, Illinois
CommonSpirit Ventures
CommonSpirit Ventures is the strategic investment arm of CommonSpirit Health, one of the largest nonprofit health systems in the United States, and describes itself as one of the longest continuously operating health system venture funds.
Nonprofit
Read the intelligence briefEditorially verified · Reviewed August 30, 2026
Same state · Same program type · Same commercialization route
Evanston, Illinois
Endeavor Health Innovation
Endeavor Health Innovation is the system's front door for co-developing, piloting and scaling new health technologies inside a nine-hospital Chicago-area system.
Academic · Nonprofit
Read the intelligence briefEditorially verified · Reviewed August 30, 2026
Same state · Same program type · Same commercialization route
Peoria, Illinois
OSF Innovation
OSF Innovation is the enterprise innovation function of OSF HealthCare, combining multidisciplinary internal teams with external partners to identify, develop and implement healthcare solutions.
Nonprofit
Read the intelligence briefEditorially verified · Reviewed August 30, 2026
Same state · Same program type · Same commercialization route
Peoria, Illinois
Nursing Innovation Lab and Nursing Innovation Fellowship
OSF HealthCare runs a dedicated Nursing Innovation Lab inside OSF Innovation that develops nurse-led solutions to improve care delivery and nursing workflow.
Nonprofit
Read the intelligence briefEditorially verified · Reviewed August 30, 2026
Reviewed August 30, 2026. External source links open in a new tab.
Confidential comparison
Request a confidential conversation about the commercial opportunities, market pathways, and capabilities within your hospital's innovation portfolio. The public directory does not score or rank programs.